Secretagogue is a peptide made up of six amino acids in the chain. Amino acids in the chain gives the peptide its structural integrity. Hexarelin is similar to growth hormone releasing hormone hexapeptide. However, it differs from the latter because of its binding and structural composition which incorporates C50H69N15O9. it has a molecular mass of 1.0242 kilo Daltons. In some cases, the peptide is often referred to as Hex and its half-life is about 70 days.
Hexarelin and the Brain
The mechanism of action of the hexarelin peptide is yet to be fully understood. However, scientific study on various organisms such as mice indicated that the peptide acts on two regions of the brain. This is important because it accentuates production and release of growth hormone from the anterior lobe of the pituitary gland. The first region that the peptide acts on is the hypothalamus.
This part of the brain is linked to the endocrine system in the central nervous system. The second region where hexarelin exerts effects on is the pituitary gland. This is the main gland in a biological system responsible for accentuating cellular function and regulation of various activities in the body. The effects of hexarelin on different parts of the brain are essential in increasing the growth hormone released per cell or per-somatotrope.
The functionality of the peptide is still under investigations as researchers and scientists are looking for avenues and the mechanism of action of the peptide. In some cases, mode of administration has proven to be effective in determining efficacy and potency of the peptide. It has been determined that hexarelin boosts performance of the biological system through enhancing various biological secretions.
This essential process ensures that the receptors and ligand are in synchrony in releasing various peptides and other biological systems. Some of the most important processes that the hexarelin peptide plays a crucial role in accentuating include elevating levels of bone density, enhancing rate or meiosis and mitosis, accelerating fat loss as well as strengthening and enhancing connective tissues and their elasticity. These potential benefits of the peptide have led to the theory that hexarelin is essential in improving muscle endurance, strength, wound healing and joint rehabilitation.
Moreover, recent studies revealed that the peptide has the ability to induce secretion of insulin-like growth factor 1. This is a protein released in the liver of the organism which plays an imperative role in growth and repair of various muscles and other tissues in the biological system. One of the main benefits of the peptide is that it does not induce production of ghrelin in the system. Therefore, it does not induce gastric emptying and gastric motility as other peptides in the category do. Ghrelin is a 28-amino acid produced in the stomach and its main function is to stimulate the sensation of hunger. Since hexarelin does not increase its level, the animal test subject can maintain certain homeostasis and food consumption.
Hexarelin and Scientific Research
There are numerous scientific studies conducted on the hexarelin peptide and it is becoming an area of interest especially for the overall functionality of the heart. The research is focused on the notion that the peptide can induce production of a better layer which could cushion the heart from adverse effects of external and internal environments. Another area of research that has gained popularity in hexarelin is the central nervous system since the peptide acts in conjunction with hypothalamus.
It has been postulated that hexarelin has the potential benefit of protecting the CNS from injuries and other related effects. Other studies on the peptide include apoptosis. Research showed that the peptide plays an essential role in cellular or programmed cellular death. The theory behind this is that the presence of hexarelin has an effect on Akt and caspase 3. The two components play crucial roles in controlling and regulating apoptosis process.
Hexarelin has been used in different scientific studies to determine its efficacy and potency on various systems. One main aim of the research is to accentuate the release of insulin-like growth factor 1. This is an important compound in a biological system that encourages muscle growth in animals. However, hexarelin does not have hunger-inducing properties like other peptides in this category.
Effects of Hexarelin on Varying Ages
Hexarelin is an effective chemical in inducing secretions in small animals and the stability of the compound is affected as well. To understand the effects of the peptide, it is imperative to compare it with other growth hormone stimulators such as GHRP 2 and GHRP 6. These peptides were administered to mice and the secretion of the peptide studied on varying ages of mice was then compared with a stable chemical 2-methyl-trp. For 10-day-old mice, tryptophan was substituted in the 2-methyl-trp and hexapeptide accentuated an increase in the volume of the growth hormone secreted in the biological system. The trials showed that hexarelin is more effective than other growth hormone secretagogues in accentuating release of growth hormone from the anterior lobe of the pituitary gland.
Hexarelin and Cardioprotective Effects
According to research on selected mice with growth hormone deficiency, it has been established that the hexarelin peptide is essential in accentuating protection of the cardiac muscle. The administration of the peptide showed a net positive effect in reducing ischemic reperfusion injury and accentuating functionality of heart muscles. Non-growth hormone-mediated effects were monitored and the rats checked throughout the week. Throughout this study, it is imperative to note that hexarelin prevented an increase in left ventricular pressure.
Moreover, it reduced reactivity of coronary vasculature to angiotensin II and coronary perfusion pressure. This is important in protecting the heart muscles and their functions. Researchers concluded that hexarelin helps reduce the damage to cardiovascular systems and this normally occurs during ischemic reperfusion that is mediated by the growth hormone via activation of various cardiac receptors.