Get Best Sermorelin Peptide Online to Fulfill Your Research Goals
Sermorelin acetate is a recent commercially-synthesized polypeptide analog of the growth hormone releasing hormone. Growth hormone releasing hormone is a naturally occurring molecule produced in the hypothalamus region of the brain. This hormone is important in accentuating production, secretion and release of growth hormones from somatotropes. It is imperative to note that naturally occurring hormones or endogenous hormones have a shorter half-life than synthetic ones. The main reason is that synthetic hormones have undergone modifications that enhance their efficacy and potency which help prevent enzymatic degradation and protease activity. Growth hormone releasing hormones was developed by Nobel laureates, A Shelley and R. Guillemin in the early 1970s. This was an era of discovery, especially of peptides. Sermorelin is available in the market and is solely for research purposes. Researchers identified that part of the growth hormone releasing hormone is very active in accentuating production and release of growth hormones from somatotrophs.
During the study, sermorelin was synthesized and was made up of 191 amino acids. These amino acids are important in adding bulk to the peptide. This is important in preventing its degradation. The sermorelin molecule has a molecular mass of 33.35796-kilo Daltons and amino acids in the sequence are linked via peptide or amide bonds. It is considered one of the most complete and similar growth hormone secretagogues to growth hormone.
Read More »
Sermorelin Features and Functions
During research, a student of Nobel laureate Wehrenberg isolated individual amino acids in the chain and found that the first 29 amino acids are effective in accentuating production, secretion and distribution of growth hormones. These amino acids are essential in stimulating the release of growth hormones from the anterior lobe of the pituitary gland. This researcher isolated a smaller part of the peptide that could accentuate production of growth hormones in big amounts just like the endogenous hormone without altering the leading sequence. It was later developed using a one-step chromatographic technique that is able to separate all the isomers in PEG or polyethylene glycol of naturally occurring growth hormone releasing hormone. Biological effects of the sermorelin peptide were observed using in vitro cultures or mice. Compared with other growth hormone releasing hormone secretagogues, researchers found this synthetic version to be more potent in accentuating release of growth hormones.
Findings from this research concluded that sermorelin is 4-5 times more potent in accentuating release of growth hormones from the anterior lobe of the pituitary gland. Recent research studies on pigs indicated that synthetic versions of the hormone releasing hormone is more effective than the natural hormone. Sermorelin is used in most research studies as a standard test for growth hormone secretion and to increase production of growth hormones from the pituitary gland. This occurs by increasing the amount of growth hormones produced per cell. In addition, inhibiting activities of somatostatin is essential in increasing the amount of growth hormones released per pulse. Exogenous hormones are effective in accentuating production of natural hormones at a higher pulse because they have been modified to cope with different environments.
Effects of Sermorelin
Sermorelin has a wide array of positive effects according to studies that have been conducted on this peptide. Because of its nature as a growth hormone releasing peptide, sermorelin increases the ability of the body to produce growth hormones in large quantities and it does not just happen after administration of the peptide. The performance of the peptide is enhanced as it increases production, secretion and distribution of growth hormones in different cells. Sermorelin has numerous benefits, making it one of the peptides under research. Benefits of sermorelin peptide can be classified into the following categories:
According to research studies done on mice, administration of the sermorelin peptide is seen to increase the performance of test mice. Studies done on brain cells of the mice showed that there was increased activity or brain cells and the clarification of different aspects were seen to be effective in performance of the peptide. In addition, when compared to placebo, the mice that were on sermorelin showed more activity and did not get tired easily. It is postulated that the sermorelin peptide increased mental sharpness and focus.
The sermorelin peptide is effective in increasing development of lean body mass. This can be attributed to the formation of new muscle cells while reducing fats cells via lipolysis. Lipolysis is the breakdown of large fats cells in the body of the test subjects into tiny molecules which are then excreted. Administration of the sermorelin peptide is seen to increase myoblastic differentiation and studies revealed that it improves muscle tone and elasticity. These are findings from rats muscles that were cut traversal. Moreover, radioimmunoassay studies showed that calcium retention improved in mice bones and this increased bone density and strengthened muscular and skeletal system.
Administration of the sermorelin peptide is seen to increase protein synthesis while inhibiting formation of fats cells in visceral and peripheral organs. It is imperative to note that this leads to stimulation of all internal organs other than the brain. In addition, studies revealed that cholesterol levels were reduced drastically. Regardless of the purpose of use, muscle pain and joint pain reduced considerably with the administration of the peptide. Studies have shown that the sermorelin peptide is effective in reducing recovery time, therefore formation of new cells is a key aspect of sermorelin. Sermorelin is seen to enhance muscle activity. When research mice were administered with the peptide, they were active for a longer period compared to those that were not administered sermorelin. Moreover, the duration of sleep in the research rats increased by 10%. This is an interesting finding, considering the fact that researchers were looking for peptides that work naturally to induce sleep.
Sermorelin works by interacting with the pituitary gland to accentuate release and secretion of growth hormones from somatotrophs located in the pituitary glands. It has been determined that the sermorelin peptide is very effective in increasing the amount of growth hormones per cell. Sermorelin increases secretion from pituitary gland and this has an up-regulatory feature on skeletal and muscle cells. According to studies, efficacy of muscle and skeletal tissues depend on the production of growth hormones from the pituitary gland. Depending on its concentration and binding, this peptide can accentuate release of copious amounts of growth hormones. In addition, sermorelin increases bone density and does this by increasing calcium ion retention which in turn increases mineral deposition in bones.
Bone resorption plays an essential role in building muscle strength and alleviating brittleness as well as fragile bones. According to mice that were administered with the sermorelin peptide, they showed sturdier bones compared to the placebo group. Since sermorelin increases the production of growth hormones it is imperative to note that the peptide is effective in accentuating protein synthesis and inhibiting formation of fats cells which are deposited in visceral and peripheral organs. Breakdown of adipose tissues accentuates weight loss and improves myoblastic differentiation. These are hypothetical benefits of sermorelin.
Sermorelin Side Effects
Just like any other peptide, it is imperative to note that sermorelin has its own side effects. Although most of these side effects are mild and do not pose any risk to a working biological system and functionality of different hormones or enzymes. While sermorelin is not risk-free, it is important to note that it has a few side effects this include
Common side effects
According to research done on rats, for about 17% of the cases, common side effects include swelling, reddening and pain in the administration site. These side effects are mild and will fade after a few hours. Moreover, they do not require any medical attention. There are less common side effects which include itching. In the test subjects, allergic reactions may occur depending on severity and dosage. Studies done on mice indicated that the sermorelin peptide does not pose any risk. Mild side effects disappear after a few days of administration. In less than 1% of research, test subjects reported hyperactivity, headache and sleepiness. However, administering sermorelin in the right dosage will reduce risk of an aneurysm, hypertension, kidney failure and heart attack.
Administration of Sermorelin
Sermorelin is supplied in freeze-dried vials and it is imperative that you purchase peptides from a reputable vendor to avoid complications during research. You can use different concentrations to monitor results. There is a certain limit that even with continued administration of sermorelin peptide, there is no significant increase in the production of growth hormones. Sermorelin should be mixed with bacteriostatic water or saline water which are medical-grade diluents. In addition, after purchasing the peptide, you should store it in a dark room at room temperature. Always reconstitute a vial for the amount that you can use for one research. This is important because it reduces chances of loss of activity or amino acid degradation. The reconstituted solution is then administered to subcutaneous layer using a technical grade needle and the mode of administration will determine its efficacy and potency. Once you have reconstituted a peptide, it is imperative that you keep the rest in a refrigerator and do not freeze it. The recommended storage temperature is between 2-8 °C and 36-46°F.
Synthetic sermorelin peptide is susceptible to changes in humidity, temperature and pressure. Therefore, it is imperative that you maintain recommended changes or else amino acids will lose its viability and working functionality. Before you reconstitute, check the vial for discoloration or suspended foreign particles. If it is discolored or has foreign particles, it is essential that you discard it. Most peptides have a saturation level that even when you increase hormonal concentration there is no effect in the production of growth hormones from the anterior lobe of the pituitary gland. A regular recommended dosage is 0.1 mg to 3.0 mg depending on your research. You can adjust the concentration to suit objectives of your research. Studies showed that using a different body for every injection increases effectiveness and also reduces excess inflammation on the administration site. In most cases, dosage depends on the weight of the test subject and do not exceed recommended. Otherwise,the peptide will go to waste and you will not achieve results.
Availability and Purchase of Sermorelin
Sermorelin is available in the market for research purpose only and it is imperative that you identify a certified supplier to avoid degradation and loss of peptide activity. Buy sermorelin peptide that works in synergy with insulin-like growth factor in accentuating release of growth hormone from the anterior lobe of pituitary gland. The sermorelin peptide has a positive net effect in increasing production and secretion of growth hormone from the anterior lobe of pituitary gland. Moreover, the choice of a good vendor with quality peptide is essential because the research can be replicated in another scientific setting. You can purchase sermorelin online from a reputable vendor for research purposes. Consistency and reproducibility of results is an essential component in any research. The credibility of the results plays an essential role in benchmarking of further studies.
The price of sermorelin in the market varies from one vendor to another. However, it is imperative that you put into consideration all important aspects before making any purchase. In case you need further information, you can request for a certificate of analysis from the vendor. Sermorelin peptide increases metabolic function and is known to increase myoblastic differentiation among other aspects. It has no effect on cortisol and prolactin levels in the system. There is a huge potential of using sermorelin to accentuate production of hormones in a biological system and according to reviews and studies were done on guinea pigs and mice sermorelin peptide is touted as one of the most effective growth hormone releasing secretagogue. A key aspect in getting the best results and understands how growth hormone releasing hormone works and how it increases production of growth hormones from the anterior lobe of pituitary gland. All peptides supplied are solely for scientific research purposes and human consumption is not allowed.